Endocrine Abstracts

A 39-year-old woman presented with a progressive enlargement of her feet, hands, tongue, nose and ears, headaches, excessive sweating, weakness and infertility. She was diagnosed with acromegaly at the age of 36, but had initially refused any kind of treatment. For a period of 3 years, the size of pituitary adenoma had enlarged from 10×12×20 to 13×19×22 mm, and the level of GH had increased from 62.4 to 104 mU/I. Preoperative administration of somatostatin ...

Diagnosis of Cushing’s syndrome (CS) can be challenging, particularly in mild cases or in cyclic disease, because of the variable, non-specific clinical manifestations and the overlap with more common medical problems. Female patient was referred to our clinic in Dec 2015, at the age of 18 years, presented with headaches, arterial hypertension (AH), excessive body hair growth, irregular menstrual periods, sleep disturbances and mood fluctuations. She smoked, but denied us...

Prolactinoma is the most frequent pituitary tumour among women of childbearing age. Cabergoline (CAB) is the treatment of choice for most of these patients. However there remain prolactinomas completely or partially resistant to standard therapy, which is rare in microprolactinomas. We present a clinical case demonstrating a positive change of the response to treatment of partially resistant microprolactinoma. A female patient, born in 1989, initially presented with dysmenorrh...

Arterial hypertension (AH) may be the initial clinical presentation of various endocrine disorders. An accurate diagnosis provides an opportunity to achieve a cure of AH in some cases. Female patient, born in 1971, was referred to endocrinologist in 2018, at the age of 47 y, presented with AH and adrenal adenoma. Since the age of 35 y (2006), after the third delivery she had been suffering from AH with paroxysmal BP surges up to 180/120 mmHg, accompanied by panic, anxiety, swe...

Most of prolactin secreting tumors excellently respond to low doses of dopamine agonists (DAs). However, management of giant, invasive prolactinomas, partially or completely resistant to DAs is a challenge. Male patient was referred to endocrinologist in 2008, at the age of 63 years, presented with headaches, pressure sensation behind the left eye, decreased vision and fatigue for the last 2 months. In 1986 (at the age of 40 years) blurred vision had appeared...

A 72-year-old male patient was referred to endocrinologist in June 2023. He had known arterial hypertension, aortosclerosis, ascending aorta and aortic valve replacement, chronic cerebral ischemia. In November 2022 stage IV cutaneous melanoma with lung metastasis had been revealed. For 6 months after tumour resection he received anti-PD-1 immune checkpoint inhibitor therapy which was well tolerated. After the 7th cycle of treatment short-term fever and skin rash had appeared, ...